Pro-M8 – the Next Generation Reproduction Programme

Pro-M8 achieves significantly higher conception rates and 6-week in-calf rates when compared to a Prosynch programme.

When cows fail to undergo luteolysis following a PG injection as part of a Prosynch programme, it results in elevated concentrations of progesterone at the time of the final GnRH (Ovurelin) injection. This reduces the probability of ovulation and conception.

Studies completed internationally have reported this rate to be between 10-27% following a single PG injection.

Elanco undertook localised, New Zealand based, studies to establish how the programme would benefit NZ farmers. The study¹ was awarded “most commendable paper published [in the New Zealand Veterinary Journal] in 2021” by the Australian and New Zealand College of Veterinary Scientists – demonstrating the quality of the research undertaken to further our knowledge around reproduction programmes that fit into the NZ landscape.

Pro-M8 adds a repeat injection of Ovuprost (PGF2α) which is given on day 8 of the Prosynch protocol. We found this increases conception rate when compared to a single day 7 Ovuprost injection.

Pro-M8 achieved 96% success in complete luteolysis.

Pro-M8 achieved relative improvements in:

Pro-M8 Primed – A breakthrough in non-cycler treatment

Through the research on Pro-M8, we were able to examine the physiological data closely and consider further improvements to the programme. These learnings allowed us to engage in additional studies and introduce Pro-M8 Primed – a new approach to ensure more cows are positioned in the optimum endocrine environment for the initiation of the Pro-M8 Programme.

The Pro-M8 Primed programme uses a PG (Ovuprost) injection 3 days prior to the progesterone device insertion and Ovurelin (GnRH) injection.

Pro-M8 Primed saw a relative improvement (compared to Pro-M8) of first service conception rate by 11.2% and 6-week in-calf rate of treated animals by 8.2%²