Pradalexᵀᴹ (pradofloxacin injection)
Pradalexᵀᴹ (pradofloxacin injection)
Bottle Size
100 mL; 250 mL
For the treatment of swine respiratory disease (SRD) associated with SRD pathogens including Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis, and Mycoplasma hyopneumoniae (M. hyo).
MODE OF ACTION
As a third-generation fluoroquinolone, Pradofloxacin has a unique structure that differs from other molecules in the class. Pradalex’s mode of action has an equal affinity to both DNA gyrase and topoisomerase IV, leading to a high potency broad-spectrum antibiotic.
In bacterial replication, the enzyme DNA gyrase unfolds the bacterial DNA for replication by DNA polymerase.
Afterward, the enzyme topoisomerase IV separates the identical DNA copies into sister cells.
Pradalex works by simultaneously binding and inactivating both DNA gyrase and topoisomerase IV inhibiting bacterial replication.
This causes the chromosome to fragment and results in rapid cell death.
Dosage and Administration
Administer once as an intramuscular injection in the neck at a dosage of 7.5 mg/kg (1.7 mL/100 lbs) body weight. Do not inject more than 5 mL (290 lbs) per intramuscular injection site.
2-day withdrawal period.
Pradalex Overview
- Pradalex is for the treatment of swine respiratory disease (SRD) associated with SRD pathogens including Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis, and Mycoplasma hyopneumoniae (M. hyo) after consideration of other non-fluoroquinolone therapeutic options.
- Featuring a unique molecular structure and mode of action, Pradalex simultaneously blocks two enzymes responsible for bacterial replication within the bacteria nucleus, leading to a high potency broad-spectrum antibiotic.
- Pradalex is a convenient, one-shot, low-volume antibiotic with a 2-day withdrawal period, offering SRD treatment protocol flexibility from nursery to finish.
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The label contains complete use information, including cautions and warnings. Always read, follow and understand the label and use directions
INDICATIONS:
Pradalex is indicated for the treatment of SRD associated with Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis and Mycoplasma hyopneumoniae in weaned swine intended for slaughter (nursery, growing, and finishing swine, boars intended for slaughter, barrows, gilts intended for slaughter, and sows intended for slaughter). Not for use in swine intended for breeding (boars intended for breeding, replacement gilts and sows intended for breeding) and in nursing piglets.
DOSAGE AND ADMINISTRATION:
Swine: Administer once as an intramuscular injection in the neck at a dosage of 7.5 mg/kg (1.7 mL/100 lb) body weight. Do not inject more than 5 mL per intramuscular injection site.
IMPORTANT SAFETY INFORMATION:
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian and prohibits the extra-label use of this drug in food-producing animals. To ensure responsible antimicrobial drug use, use of pradofloxacin should be limited to treatment of swine respiratory disease (SRD) in swine only after consideration of other non-fluoroquinolone therapeutic options.
Not for use in humans. Keep out of reach of children. Avoid contact with eyes and skin. Individuals with a history of hypersensitivity to quinolones should avoid this product. Not for use in animals intended for breeding. Not for use in nursing piglets. Quinolones should be used with caution in animals with known or suspected central nervous system (CNS) disorders. Mild to moderate inflammatory changes of the injection site may be seen in swine treated with Pradalex. Pradalex has a pre-slaughter withdrawal time of 2 days for swine. See package insert for additional safety information.
