DIRECTIONS FOR USE

Read package insert prior to use.
Intramuscular injection into the anterior half of the neck.

DOSE RATE
Oestrus synchronisation

Day 0: 1 mL GnRH
Day 7: 2 mL PGF2α
Day 9: 1 mL GnRH
 

1. Oestrus synchronisation

Oestrus synchronisation is a procedure developed to synchronise ovulation for timed breeding. Procedures involving a combination of PGF2α/GnRH have been found to be superior in terms of pregnancy rate and calving to conception intervals in dairy cattle. Using a combination of PGF2α/GnRH also result in a more precise synchronisation hence allowing fixed-time insemination. Fixed-term insemination in turn allows insemination of large groups of cows together, without the need for oestrus detection.

The PGF2α/GnRH procedure for dairy cattle reproductive management is as follows:

(i) Day 0 – GnRH administration: GnRH induces ovulation and luteinisation of dominant follicles present at the time of treatment and causes the smaller follicles to undergo atresia. A new follicular wave is subsequently recruited and a new dominant follicle gradually emerges.

(ii) Day 7 – PGF2α administration: 7 days after the first treatment with GnRH, PGF2α is administered. Administration of PGF2α causes luteolysis of the GnRH induced corpus luteum. The new dominant follicle is ready to ovulate 2 – 3 days later.

(iii) Day 9 – GnRH administration: The second GnRH dose induces an LH surge, which further synchronises the dominant follicle, resulting in ovulation of predictable timing, allowing fixed time insemination 8 – 24 hours later.

(iv) Insemination 8 – 24 hours after the second GnRH, regardless of the presence or absence of visible oestrus.
 

2. Treatment of Anoestrus

(i) Day 0 – GnRH administration and insertion of P4 device.

(ii) Day 7 – PGF2α administration

(iii) Day 7 – 9 AI to detected oestrus during next 72 hours.

(iv) Day 10 – GnRH administration and Fixed Time AI of all non-bred cows during the next 24 hours.

3. Prevention of delayed ovulation

Delayed ovulation can result in the reduction of the rate of conception due to asynchrony between ova and sperm at the time of artificial insemination (AI).

Delayed ovulation can be prevented by the administration of Ovurelin, which stimulates the release of LH and hence induces ovulation.
 

4. Improvement of postpartum fertility

It is important that normal ovarian cyclical activity resume in the early post-partum period to minimise the calving to conception interval or ‘days open’.

Ovurelin given in the first 40 days of the postpartum period may initiate the ovarian cyclical activity to resume, and reduce the incidence of postpartum infertility in cows.
 

5. Treatment of cystic ovaries

Cystic ovaries are an infertility problem in dairy cattle, which may be of single or multiple and of follicular or luteal origin. Clinical signs of ovarian cysts include irregular oestrus cycles, anoestrus and nymphomania. Ovarian cysts can be diagnosed by rectal palpation of the structures on one or both ovaries. Treatment of cystic ovaries with Ovurelin may result in the recommencement of normal cyclical activity, through the response of ovarian cysts to the released LH induced by Ovurelin. Ovurelin given in the first 40 days of the postpartum period may initiate the ovarian cyclical activity to resume, and reduce the incidence of postpartum infertility in cows.
 

WITHHOLDING PERIODS

Milk and Meat: NIL

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Copyright

Ovurelin™ is registered under the ACVM Act 1997 No: A009949
Ovurelin, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.
Elanco New Zealand, 106 Wiri Station Road, Manukau, Auckland 2104.
www.elanco.com I 0800 446 121. © 2023 Elanco. PM-NZ-23-0359