Hemicell™️ (β-mannanase)

Hemicell is a diet additive for poultry that maximizes the energy available for growth and performance.

Why Choose Hemicell?

Safety Profile

Hemicell is safe to use with other enzyme products.

Increased Benefits

The value of Hemicell increases in diets that have high β-mannans content.

Fast-acting

Starts working immediately after ingestion to maximize performance.

Hemicell is a highly specific, patented enzyme for poultry diets. It helps maximize flock performance by mitigating an immune response caused by β-mannans, found in feed ingredients like soybean meal.^1-7 

Frequently Asked Questions

: β-mannans (beta-galactomannans) are antinutritive fibers found in common feed ingredients, including soybean meal and other leguminous feeds.⁸ β-mannans have a molecular pattern similar to some pathogens, which triggers a feed-induced immune response (FIIR) in poultry.^3,9 This unnecessary innate immune system stimulation consumes energy and other valuable nutrients. 
: Hemicell (β-mannanase) is a nutrient-sparing enzyme that breaks down β-mannans. Most enzyme products are energy-releasing enzymes — they "open up" feed components the animal is unable to access on its own. Hemicell is different; it's a unique and patented energy-sparing enzyme. By breaking down β-mannans in soybean meal,^9-10 Hemicell minimizes the metabolizable energy (ME) loss caused by the FIIR from β-mannans, allowing more energy to be available for growth and performance.⁹ 
: In a comprehensive review of seven Hemicell trials, feeding Hemicell from day zero to 42-43 days of age was shown to break down β-mannans (β-galactomannans) in soybean meal, thus minimizing the feed-induced immune response (FIIR). This resulted in improvements in three factors: market weight, feed conversion ratio (FCR) and weight-adjusted feed conversion (WAFC).¹⁰ 
: Yes, Hemicell is suited to layers, broilers and turkeys, as well as pigs.

¹ Song, W., Wang, G., Chen, L. et al. 1995. “A Receptor Kinase-Like Protein Encoded by the Rice Disease Resistance Gene, Xa21.” Science. 270: 1804-1806. 

² Beutler, B., Jiang, Z., Georgel, P. et al. 2006. “Genetic Analysis of Host Resistance: Toll-Like Receptor Signaling and Immunity at Large.” Annu. Rev. Immunol. 24: 353-389. 

³ Ausubel, F. 2005. “Are innate immune signaling pathways in plants and animals conserved?” Nature Immunol. 6(10): 973-979. 

⁴ Didierlaurent, A., Simonet, M. and Sirard, J-C. 2005. “Innate and acquired plasticity of the intestinal immune system.” Cellular and Molecular Life Sciences. 62: 1285-1287. 

⁵ Stahl, P. and Ezekowitz, R. 1998. “The mannose receptor is a pattern recognition receptor involved in host defense.” Curr. Opin. Immunol. 10(1): 50-55. 

⁶ Sambrook, I. and Rainbird, A. 1985. “The effect of guar gum and level and source of dietary fat on glucose tolerance in growing pigs.” Brit. J. Nutr. 54(01): 27-35. 

⁷ Daskiran, M., Teeter, R., Fodge, D. and Hsiao, H. 2004. “An Evaluation of Endo-ß-D-mannanase Hemicell Effects on Broiler Performance and Energy Use in Diets Varying in ß-mannan Content.” Poultry Sci. 83: 662-668. 

⁸ Hsiao, H., Anderson, D. and Dale, N. 2006. "Levels of β-mannan in Soybean Meal." Poultry Sci. 85: 1430-1432. 

⁹ Zhang, L. and Tizard, I. (1996). “Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera gel.” Immunopharmacology. 35, 119-128. 

¹⁰ Korver, D. 2006. "Overview of the Immune Dynamics of the Digestive System." J. Appl. Poultry Res. 15: 123-135. 

Hemicell,  Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

Hemicell™️ (β-mannanase)

Why Choose Hemicell?

Frequently Asked Questions

What are β-mannans?

How does Hemicell work?

Is there evidence that Hemicell works?

Can I give Hemicell to layer chickens?